• Congratulation Dr. Das & Dr. Majumder for the paper in J Biomol Struct Dyn 2022
  • SSBTR is 80G Certified Society
  • SSTR members published a policy paper on Translational Research
  • SSBTR received 12A Certificate
  • SSBTR Members published a Policy Paper on Systems Medicine Education for Developing Countries
  • Congratulation SSBTR Members for publishing a Policy Paper on Systems Medicine
  • Congratulation Mr. Dhar & Dr. Majumder for publishing research report on leukemia treatment
  • Here, in this section we will be intermittently displaying the achievements of our hon'ble members so stay tuned and keep watching this space.

Society for Systems Biology & Translational Research

( Regn. No. S/2L/No. 10387 of 2013-14 of West Bengal Act XXVI of 1961 )
( 12A Certificate Memo No. CIT(E)/10E/745/2017-18/18-19/S-0042/0344-46 )
( 80G Order No. ITBA/EXM/S/80G/2018-19/1014606278(1) dated 27/12/2018 )
Ordinary Member
bhaskar saha
9422319945 | sahab@nccs.res.in
National Centre for Cell science, Ganeshkhind, Pune 411007
Thursday, 02nd January, 1964
Same as Present Address
National Centre for Cell science, Pune


  • Immuno-suppression in Visceral Leishmaniasis [VL].
  • Costimulatory function of macrophages in VL, Tuberculosis and Salmonellosis.
  • Requirement for CD28 costimulation in toxic shock syndrome.
  • Requirement for CD28 and CTLA-4 in murine leishmaniasis
  • T cell costimulation and CD40 signaling in leishmaniasis. Anti-leishmanial vaccine and drugs. Toxic Shock Syndrome. DC-mediated anti-tumor immunity. Angiogenesis and tumor therapy.  Toll-like receptor signaling. 

Research Fellow: Indian Institute of Chemical Biology, Calcutta (1988 --  '93).

Research Associate: Inst. of Microbial Technology; PGIMER, Chandigarh (1994 : Jan  -- May).

Post-doctoral Fellow: Naval Medical Research Institute [NMRI] (1994 – ’96).

Principal Investigator at NMRI, and Faculty, Dept of Medicine, USUHS, Bethesda, USA (1996 --- '97) .

Scientist: NCCS, Pune (1998-Present).

Original articles:

1.       Mallick S, Dutta A, Chaudhuri A, Mukherjee D, Dey S, Halder S, Ghosh J, Mukherji D, Sultana SS, Biswas G, Lai TK, Patra P, Sarkar I, Chakraborty S, Saha B, Acharya K, Pal C. Successful therapy of murine visceral leishmaniasis with astrakurkurone, a triterpene isolated from mushroom, involves cooperation of TLR9 and induces protective cell mediated immunity. Antimicrobial Agents Chemother. [In press]. 2016.

2.       Bandyopadhyay S, Mahapatra SK, Paul Chowdhury B, Jha MK, Das S, Halder K, Bhattacharyya Majumdar S, Saha B, Majumdar S. Toll-Like Receptor 2 targeted rectification of impaired CD8+ T cell functions in experimetal Leishmania donovani infection reinstates host protection. Med. Microbiol. Immunol. [In Press]. 2016.

3.       Bandyopadhyay S, Chandel HS, Singh S, Roy S, Krishnasastry MV, Saha B. Counteractive functions are encrypted in the residues of CD154. Human Immunol. [In press]. 2015. 

4.       Mukherjee B, Paul J, Mukhopadhyay R, Mukherjee S, Naskar K, Sundar S, Dujardin J-C, Saha B, Roy S. Antimony Resistant Leishmania donovani exploits miR-466i to deactivate host MyD88 for regulating IL-10/12 level during early hours of infection. J. Immunol. [In press]. 2015. 

5.       Pandey SP, Doyen N, Mishra GC, Saha B, Chandel HS. TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages. Exp. Parasitol. 154:82-86. 2015.

6.       Gangalum P, de Castro W, Vieira L, Dey R, Rivas L, Majumdar S, Singh S, Saha B. Miltefosine requires platelet activating factor receptor for its anti-leishmanial function.  J. Immunol. 194: 5961-5967. 2015. 

7.       Mukherjee D, Ghosh AK, Datta M, Mitra E, Mullick S, Saha B, Reiter RJ, and Bandyopadhyay D. Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin. J. Pineal. Res. 58: 275-290. 2015.

8.       Chakraborty S, Srivastava A, Jha MK, Nair A, Pandey SP, Srivastava N, Kumari S, Singh S, Musti KV, Saha B. Inhibition of CD40-induced N-Ras activation reduces Leishmania major infection. J. Immunol. 194: 3852 - 3860. 2015.

9.       Paul Chowdhury B, Das S, Majumdar S, Bandyopadhyay S, Bhattacharyya Majumdar S, Saha B, Majumdar S. Arabinosylated lipoarabinomannan 1 modulates IFN-γ responsiveness in Leishmania donovani infected murine macrophages. PLoS One. 10(2):e0117247. 2015.

10.    Das S, Ganguly A, Saha B, Das VNR, Das P. Species-specific unmethylated CpG-motifs in the L. donovani DNA regulate TLR9-dependent delay of programmed cell death in macrophages. J. Leukoc. Biol. 97: 363-378. 2015.

11.    Pandey SP, Chandel HS, Srivastava S, Selvaraj SK, Jha MK, Shukla D, Ebensen T, Guzman CA, Saha B. BPPcysMPEG, a diacylated lipopeptide ligand of TLR6, plays host-protective role against Leishmania major infection. J. Immunol. 193: 3632 - 3643. 2014.

12.    Khan TH, Srivastava N, Sareen A, Mathur RK, Chande AG, Krishnasastry MV, Roy S, Mukhopadhyaya R, Saha B. SHP-1 plays a crucial role in CD40 signaling reciprocity. J. Immunol. 193: 3644 - 3653. 2014.

13.    Chandel HS, Pandey SP, Shukla D, Lalsare K, Selvaraj SK, Saha B. TLRs and CD40 modulate each others expression affecting Leishmania major infection. Clin. Exp. Immunol. 176: 283-90. 2014

14.    Selvaraj SK, Raundhal M, Patidar A, Saha B. Anti-VEGF antibody enhances the anti-tumor effect of CD40. Int. J. Cancer. 135: 1983-1988.  2014.

15.    Padwal M, Sarma U, Saha B. Comprehensive logic based analyses of toll-like receptor 4 signal transduction pathway. PLoS One. 9(4): e92481. 2014.

16.    D Sathawane, RS Kharat, S Halder, S Roy, R Swamy, R Patel, Saha B. Monocyte CD40 expression in head and neck squamous cell carcinoma (HNSCC). Human Immunol. 74:1-5. 2013.

17.    MM Naiyer, S Saha, V Hemke, S Roy, S Singh, KV Musti, Saha B. Identification and characterization of a human IL-10 receptor antagonist. Human Immunol. 74:28-31. 2013.

18.    Penke LR, Sudan R, Sathishkumar S, Saha B. Prostaglandin E2 receptors have differential effects on Leishmania major infection. Parasite Immunol. 35:51-54. 2013.

19.    Kasas S, Radotic K, Longo G, Saha B, Alonso-Sarduy L, Dietler G, Roduit C. A Universal Fluid Cell for the Imaging of Biological Specimens in the Atomic Force Microscope. Microsc. Res. Tech. 76:357-63. 2013.

20.    Mallick S, Halder S, Dutta A, Dey S, Paul K, Maiti S, Bandyopadhyay C, Saha B, Pal C. Chromone linked nitrone derivative induces the expression of iNOS2 and Th1 cytokines but reduces the Th2 response in experimental murine visceral leishmaniasis. Int. Immunopharmacol. 15:772-779. 2013.

21.    Srivastava S, Pandey SP, Jha MK, Chandel HS, Saha B. Leishmania expressed lipophosphoglycan interacts with Toll-like receptor (TLR)-2 to decrease TLR-9 expression and reduce anti-leishmanial responses.  Clin. Exp. Immunol. 172: 403-409. 2013.

22.    Jesan T, Sarma U, Halder S, Saha B, Sinha S. Branched motifs enable long-range interactions in signaling networks through retrograde propagation. PLoS One. 8: e64409. 2013.

23.    Sarma U, Gade PM, Saha B.  A mathematical model for dynamics of CD40 clustering. J. Synth. Systems Biol. 7: 197-208. 2013.

24.    Pati NB, Vishwakarma V, Selvaraj S, Dash S, Saha B, Singh N, Suar M.  Salmonella Typhimurium TTSS-2 deficient mig-14 mutant shows attenuation in immuno-compromised mice and offers protection against wild-type Salmonella Typhimurium infection. BMC Microbiology. 13: 236. 2013.

25.    Majumder S, Dey R, Bhattacharjee S, Rub A, Gupta G, Bhattacharyya Majumdar S, Saha B, Majumdar S. Leishmania-induced biphasic ceramide generation in macrophages is crucial for uptake and survival of the parasite. J. Inf. Dis. 205:1607-16. 2012.

26.    Roduit C, Longo G, Benmessaoud I, Volterra A, Saha B, Dietler G, Kasas S. Stiffness tomography exploration of living and fixed macrophages. J Mol Recognit. 25: 241-246. 2012.

27.    Sarma U, Sareen A, Maiti M, Kamat V, Sudan R, Pahari S, Srivastava N, Roy S, Sinha S, Ghosh I, Chande AG, Mukhopadhyaya R, Saha B. Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases. PLoS One. 7(7):e39898. 2012.

28.    Adhikari A, Gupta G, Majumder S, Banerjee S, Bhattacharjee S, Bhattacharya P, Kumari S, Haldar S, Bhattacharya Majumdar S, Saha B, Majumdar S. Mycobacterium indicus pranii re-establishes host protective immune response in Leishmania donovani infected macrophages: Critical role of IL-12. PLoS One. 7(7):e40265. 2012.

29.    Vishwakarma V, Pati NB, Chandel HS, Sahoo SS, Saha B, Suar M. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immuno-compromized mice. PLoS One. 7(12):e52043. 2012.

30.    Khan S, Alonso L, Roduit C, Saha S, Tacchini-Cottier F, Kasas S, Dietler G, Krishnasastry MV, Saha B.  Differential peptide binding to CD40 evokes counteractive responses. Human Immunol. 73: 465-9. 2012.

31.    Adhikari A, Majumder S, Banerjee S, Gupta G, Bhattacharya P, Bhattacharyya Majumdar S, Saha B, Majumdar S. Mycobacterium indicus pranii (Mw) mediated protection against Visceral Leishmaniasis:  Involvement of TLR4 Signaling. J. Antimicrob. Chemother. 67: 2892-902. 2012.

32.    Sudan R, Srivastava N, Pandey SP, Majumdar S, Saha B.  Reciprocal regulation of Protein kinase C isoforms results in differential cellular responsiveness. J. Immunol. 188: 2328-37. 2012.

33.    Roduit C, Saha B, Alonso-Sarduy L, Volterra A, Dietler G, Kasas S. OpenFovea: open-source AFM data processing software. Nature Methods. 9: 774-775. 2012.

34.    Srivastava N, Sudan R, Saha B. CD40-modulated dual-specificity phosphatases MAPK Phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J. Immunol. 186: 5863-5872. 2011.

35.    Kumari S, Singh S, Saha B, Paliwal P. Leishmania major MAP kinase 10 is protective against experimental L. major infection. Vaccine. 29: 8783-8787. 2011.

36.    Bhattacharya P, Bhattacharjee S, Gupta G, Majumder S, Adhikari A, Mukherjee A, Bhattacharya-Majumdar S, Saha B, Majumdar S. Ara-LAM mediated protection in Visceral leishmaniasis through up-regulation of TLR2 signaling: An immunoprophylactic approach. J. Infect. Dis.  202:145-55. 2010.

37.    Paila YD, Saha B, Chattopadhyay A. Amphotericin B Inhibits Entry of Leishmania donovani into Primary Macrophages. Biochem. Biophys. Res. Commun. 399: 429-33. 2010.

38.    Martin S, Pahari S, Sudan R, Saha B. CD40 signaling in CD8+CD40+ T cells turns on contra-T regulatory cell functions. J. Immunol. 184: 5510-5518. 2010. 

39.    Martin S, Agarwal R, Murugaiyan G, Saha B. CD40 expression levels modulate regulatory T cells in Leishmania donovani infection. J. Immunol. 185:551-559. 2010. 

40.    Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, Mukhopadhyay R, Saha B. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nature Immunol. 10: 273-280. 2009.  

41.    Wadhone P, Maiti M, Agarwal R, Kamat V, Martin S, Saha B. Miltefosine promotes IFN-g-dominated anti-leishmanial immune response. J. Immunol. 182:7146-7154. 2009. 

42.    Murugaiyan G, Saha B. Pro-tumor vs anti-tumor functions of IL-17. J Immunol. 183: 4169-75.  2009

43.    Khan AA, Priya S, Saha B. IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice. PLoS One. 4(12):e8473. 2009.

44.    Gupta S, Mishra GC, Ramanamurthy B, Saha B, Mitra D. IL12 is necessary for the priming of CD4+ T cells during the elicitation of HIV-1 gp120-specific cytotoxic T-lymphocyte function. Immunology. 124:553-561. 2008.

45.    Aslam Ali Khan, Sunil Martin and Bhaskar Saha. SEB-induced signaling leads to biphasic TNF-alpha productions. J. Leukoc. Biol. 83: 1363-1369. 2008. 

46.    Shalini Gupta, GC Mishra, B Ramanamurthy, Saha B, D Mitra. Human Immunodeficiency Virus-1 Tat suppresses gp120 specific T-cell response in IL-10 dependent manner. J Immunol. 180:79-88. 2008.

47.    Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Differential CD40/CD40L expression results in counteracting anti-tumor immune responses. J Immunol.  178: 2047 – 2055. 2007.

48.    Murugaiyan G, Martin S, Saha B. Levels of CD40 expression on dendritic cells dictate tumour growth or regression. Clin. Exp. Immunol. 149: 194-202. 2007.

49.    N Majumder, R Dey, RK Mathur, S Dutta, D Roy, M Maitra, S Ghosh, B Saha, S Majumdar. IL-10 plays a dual role in murine peritoneal macrophages treated with man- and ara-LAM.  Glycoconj. J. 23: 675- 686. 2006.

50.    Jayati Mookerjee Basu, A Mookerjee, P Sen, S Bhaumik, P Sen, S Banerjee, K Naskar, SK. Choudhuri, Bhaskar Saha, S Raha, and Syamal Roy. Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages. Antimicrob. Agents and Chemother.  50: 1788 -1797. 2006. 

51.    Manish Bodas, Nitya Jain, Amit Awasthi, B Ramanamurthy and Bhaskar Saha. IL-2 is a key cytokine that regulates susceptibility to Leishmania infection. J Immunol. 177: 4636- 4643. 2006. 

52.    G Murugaiyan, Reena Agrawal, Gyan C Mishra, Debashis Mitra, and Bhaskar Saha. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol. 177: 6642 – 6649.  2006.

53.    Kaul-Ghanekar R, Majumdar S, Jalota A, Gulati N, Dubey N, Saha B, Chattopadhyay S. Abnormal V (D) J recombination of TCRb locus in SMAR1-transgenic mice. J Biol Chem.  280: 9450-9459.  2005.

54.    Ram Kumar Mathur, Amit Awasthi, Pallavi Wadhone, B Ramanamurthy, Bhaskar Saha. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteractive immune responses.  Nature Medicine. 10: 540 - 44. 2004.

55.    Bhaskar Saha, AMDJ Tonkal, Simon L Croft and Syamal Roy. Mast cells at the host-pathogen interface: Host-protection versus immune evasion.  Clin Exp Immunol. 137: 19-23. 2004.

56.    K. Venuprasad, Subhasis Chattopadhyay, and Bhaskar Saha. CD28 signaling in neutrophil induces T cell chemotactic factor(s) modulating T cell response. Hum.  Immunol. 64: 38 - 43. 2003.

57.    A Awasthi, R K Mathur, AA Khan, B Joshi, N Jain, S Sawant, D Mitra, and Bhaskar Saha. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J. Exp. Med.  197:1037-43. 2003.

58.    Deshpande M, Venuprasad K, Parab PB, Saha B and Mitra D. A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. Human Immunol. 63: 20-23. 2002. 

59.    K Venuprasad, P Banerjee, S Sharma, S Pal, P Parab, D Mitra, Bhaskar Saha. Human neutrophil expressed CD28 interacts with macrophage expressed B7 to induce IFN-γ and restrict Leishmania growth. J. Immunol. 169: 920-928. 2002.

60.    K Gray, R P Stephan, R-G Apilado, DA Lill-Elghanian, KP Lee, Bhaskar Saha, and PL Witte. Expression of CD28 by bone marrow stromal cells and Its Involvement in B Lymphopoiesis.  J. Immunol. 169: 2292 - 2302. 2002.

61.    K Venuprasad, PB Parab, P Banerjee, S Sharma, DVR Prasad, M Deshpande, S Pal, DK Mitra, D Mitra, Bhaskar Saha. Immunobiology of CD28 expression on human peripheral blood neutrophils. I. CD28 plays important role in regulating neutrophil migration by modulation of CXCR-1 expression. Eur. J. Immunol.  31: 1536-43. 2001.

62.    G Das, H Vohra, Bhaskar Saha, Gyan C Mishra. Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection. Scand. J. Immunol. 52: 515-518. 2000. 

63.    Bhaskar Saha, Abha Saini, Rhonda Germond, P J Perrin, Dave Harlan and Thomas A Davis. Susceptibility or resistance to Leishmania infection is dictated by bone marrow derived-macrophages developed under the influence of IL-3 or GM-CSF.  Eur. J. Immunol. 29: 2319 - 2329. 1999.

64.    G Das, H Vohra, Bhaskar Saha and GC Mishra. Leishmania infection of a susceptible host results in apoptosis and decreased Th1 cytokine production.  Scand. J. Immunol.   4 9: 307-310. 1999.

65.    G Das, H Vohra, Bhaskar Saha, JN Agrewala and GC Mishra. Experimental tuberculosis results in Th1 apoptosis sparing Th2 cells.   Clin. Exp. Immunol. 115: 324 - 328. 1999.

66.    D Chattopadhyay, T Mukherjee, P Pal, Bhaskar Saha and R Bhadra. Altered membrane permeability as the basis of bactericidal action of methdilazine.  J. Antimicrob. Chemother.  41: 83 - 6. 1998.

67.    Gobardhan Das, H Vohra, K Rao, Bhaskar Saha, JN Agrewala and Gyan C Mishra. Leishmania donovani infection of a susceptible host results in apoptosis of Th1-like cells: rescue of anti-leishmanial CMI by providing Th1-specific bystander costimulation.  Microbiol. Immunol. 42: 795 - 801. 1998.

68.    Bhaskar Saha, S Chattopadhyay, R Germond, D Harlan and PJ Perrin.  CTLA4 induces Th subset differentiation and alters the course of Leishmania infection. Eur. J.  Immunol.  28: 4213-18. 1998.

69.    Sudhir Gupta, H Vohra, Bhaskar Saha, C Nain, NK Ganguly.. Macrophage-T cell interaction in murine salmonellosis: selective down-regulation of ICAM-1 and B7 molecules in infected macrophages and its probable role in cell-mediated immunity. Eur. J. Immunol. 26: 563-570. 1996

70.    Larry D Palmer, Bhaskar Saha, Richard J Hodes and Ryo Abe.  The role of CD28 in immune mediated responses against MMTV.  J. Immunol. 156: 2112-2118. 1996.

71.    Bhaskar Saha, B Jaklic, DM Harlan, CH June and Ryo Abe. Prevention of lethal toxic shock by blocking T cell costimulation. J. Immunol. 157: 3869 - 3875. 1996.

72.    Bhaskar Saha, DM Harlan, CH June, KP Lee and Ryo Abe.  Protection against lethal toxic shock by targeted disruption of the CD28 gene. J. Exp. Med. 183: 2675 - 2680. 1996. 

73.    Bhaskar Saha, G Das, H Vohra, NK Ganguly and Gyan C Mishra.  Macrophage - T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania-infected macrophages and its implication in the suppression of cell-mediated immunity. Eur. J. Immunol. 25: 2492 - 2498. 1995. 

74.    Bhaskar Saha, D Bandopadhyay and Syamal Roy. Immunobiological studies in experimental visceral leishmaniasis. IV. Kinetics of evolution of disease promoting vs. host-protective cells of monocyte-macrophage lineage and their characterization.  Scand. J Immunol.42: 540-546. 1995.

75.    Bhaskar Saha, G Das, H Vohra, NK Ganguly and Gyan C Mishra. Macrophage - T cell interaction in experimental mycobacterial infection. Selective regulation of costimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response. Eur. J. Immunol. 24: 2618 - 2624. 1994. 

76.    Bhaskar Saha, Saroj K Basak and Syamal Roy. Immunobiological studies in experimental visceral leishmaniasis. III. Cytokine mediated regulation of parasite replication.  Scand. J. Immunol. 37: 155-58. 1993.

77.    Saroj K Basak, Bhaskar Saha, A Bhattacharya and Syamal Roy.  Immunobiological studies in experimental visceral leishmaniasis. II. Adherent cell-mediated down-regulation of delayed-type hypersensitivity response and up-regulation of B cell activation.  Eur. J. Immunol. 22:2041-45. 1992.

78.    Saha B, Roy HN, Pakrashi A, Chakraborty RN, Roy S. Immunobiological studies in experimental visceral leishmaniasis. I. Changes in lymphoid organs and their possible roles in pathogenesis. Eur. J. Immunol. 21:577-81. 1991. 


1.       Mukherjee D, Roy S, Mukherjee A, Saha B.  Spatio-temporal regulation of PKC isoforms imparts signaling specificity. Front. Immunol. [In press]. 2016.

2.       Fischer-Fodor Eva, Miklasova N, Berindan-Neagoe I, Saha B.  Iron, inflammation and invasion of cancer cells. Clujul Medical [In press]. 2015.

3.       Chandel HS, Pandey SP, Roy S, Doyen N, Bhaskar Saha. CD40-TLR cross-talk in anti-leishmanial immune response.  Front. Immunol. 5: 220. 2014.

4.       G Murugaiyan, Bhaskar Saha. The paradoxical anti-tumor functions of IL-27. Trends Mol. Med. 19: 108-116. 2013.

5.       Sunil Martin, Bhaskar Saha, JL Riley. The Battle over mTOR: an Emerging Theatre in Host-Pathogen Immunity. PLoS Pathogen. 8 (9):e1002894. 2012.

6.       Suvercha Bharadwaj, Neetu Srivastava, Raki Sudan and Bhaskar Saha. Modulation Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy. J. Biomed. Biotech. 2010: 109189 (1-13). 2010.

7.       R Dey, M Jadhav, S Pahari, S Khan, N Srivastava, Bhaskar Saha. The functional paradox in host-parasite interaction dictates fate of the parasite. Future Microbiol. 2:425-37. 2007.

8.       Gopal Murugaiyan, Sunil Martin, Bhaskar Saha. CD40-induced angiogenesis: forming countercurrent conduits for tumor escape or immune invasion? Trends Immunol. 28:467-73. 2007.

9.       Ranadhir Dey, Srijit Khan, Bhaskar Saha.  A novel functional approach towards identifying definitive drug Targets. Curr. Med. Chem. 28:467-73. 2007.

10.    Ram K Mathur, Amit Awasthi, Bhaskar Saha.  The conundrum of CD40 function: Host-Protection or Disease-promotion. Trends Parasitol. 22: 117 - 122. 2006.

11.    G Murugaiyan, SK Basak and Bhaskar Saha. Tumor-induced dendritic cell paralysis: A treatment regimen against cancer. Curr. Immunol. Rev. 2: 261 - 272. 2006.

12.    G Murugaiyan, S Basak and Bhaskar Saha. Dendritic cell-based immunotherapy: A promising approach for treatment of cancer. Gene Ther. Mol. Biol. 9: 343 – 358. 2005. 

13.    A Awasthi, R Mathur, B Saha. Immune response to Leishmania infection. Ind J Med Res. 119: 238-258. 2004.

14.    A Ashtekar and Bhaskar Saha. Poly’s plea: membership to the club of APCs. Trends Immunol. 24:485-90. 2003.

15.    PJ Blair, JL Riley, RG Carroll, DC St. Louis, B Levine, Bhaskar Saha, KP Lee, P Perrin, DM Harlan, CH June. CD28 co-receptor signal transduction in T cell activation. Biochem. Soc. Trans. 27:567-571. 1997.

16.    Bhaskar Saha, Saroj K Basak, K Das, A Bhattacharya and Syamal Roy. Functional analysis of adherent cells in experimental visceral leishmaniasis, Eds. AN Bhaduri, MK Basu, AK Sen and Sushil Kumar. Current Trends in Leishmania Research. Pg. 41-48. CSIR Publications, New Delhi, India. 1993.


1.       Saha B. Antigens [version 3.0]. Encyclopedia of Life Science. John Wiley and Sons, Ltd. UK 2015.

2.       Padwal MK, Sarma U, Sudan R, Bhaskar Saha. Macrophage kinases in Leishmaniasis. Chapter 11. Pages 217 – 233.  In Protein phosphorylation in parasites.  Eds. Christian Doerig, Gerald Spath, Martin Weise.  Wiley-VCH, Germany. 2014. 

3.       Ghosh SK, Lalsare K, Bhaskar Saha. Leishmania modulates Toll-Like receptor signaling in macrophages. Ch. 08. In Leishmania: Current Biology and control. [Eds. Subrata Adak & Rupak Datta]. Caister Academic Press and Horizon Press. UK. 2014.

4.       Bhaskar Saha. CD40 and Cancer therapy. Chapter 10. Pages 104 - 110. In Treatment of Advanced Stage Cancers Current Status and Emerging Frontiers. Narosa Publications. New Delhi. 2009.

5.       Ashtekar AR and Bhaskar Saha. Polymorphonuclear neutrophils as antigen presenting cells. In Antigen presenting cells: From mechanisms to drug development. Pgs 415-39. Eds. H Kropshofer and AB Vogt. Wiley-VCH Publications, Germany. 2005

6. Hati AK, Roy S, Saha B, Bharati K. Basic Concepts in Immunology. Allied Book Agency. Kolkata. 2014.

  1. Continued Superior Performance Award: 1996: Henry M Jackson Foundation, USA.
  2. FIMSA Young Scientist Travel Award: 2002: FIMSA:
  3. National Bioscience Award for Career Development: 2007: DBT, Govt. of India.
  4. Shanti Swarup Bhatnagar Award [Biological Sciences]: 2009: CSIR, Govt. of India.
  5. Platinum Jubilee Lecture: Centenary Year of Indian Science Congress, Kolkata. 2011.
  6. Fellow (FNASc, Allahabad)
  7. Fellow (FASc, Bangalore)
  8. Fellow (FWAST, Calcutta) 

  1. Neonatal vaccination against Leishmaniasis, DST,
  2. Neonatal priming against Toxic Shock Syndrome, LSRB
  3. Role of costimulation in Anti-leishmanial immune response,DBT
  4. Engineering Dendritic cells for cancer therapy, DBT

  5. Delineating CD40 signaling in Leishmania-infected macrophages, CSIR

  6. System Biology of CD40 signaling in macrophages, DBT

  7. Molecular mechanism of CTL dysfunction in HIV, DBT infection

  8. Association between CD40, chemokines and T cell responses, DBT

  9. Leishmania infection in newly derived inbred mouse strains, DST

  10. Do phosphatases regulate the CD40 signaling rendezvous? DST

  11. Membrane properties affect CD40 signaling, DST

  12. Immunotherapy for leishmaniasis / Cancer, DBT

  13. Novel strategies to combat leishmaniasis, ICMR

  14. CD40 clustering on macrophage membrane, DBT

  15. Studies on the Inter-TLR regulation of TLR expression and function, DBT

Reviewer:  J. Exp. Med., J. Immunol., J. Inf. Dis., J. Leuk. Biol., PLoS Pathogen, PLoS Negl. Trop. Dis., PLoS One, Eur. J Immunol., Immunobiol., Immunol. Cell Biol., J. Antimicrob. Chemother., J. Infection, J. Clin. Invest., Cell. Immunol., Scan. J. Immunol., Trends Parasitol. Trends Immunol., Trends Mol. Med., Infect. Immun., Cytokine, BMC Journals.  Clin. Transl. Immunol.  

 Editor: PLoS One, Cytokine, Clinical and Translational Immunology


1.       Indian Immunology Society;

2.       Society for Biological Chemists; 

3.       Task Force on “Infectious Disease Biology” 2006-2008 (Dept Biotechnology, New Delhi)

4.       Task force on “BioCare”: 2009-2012 (Dept Biotechnology, New Delhi)

5.       Task Force on “Vaccine” (ICMR): 2008-2009;

6.       Interim Advisory Committee: 2008-2009: UNESCO Centre (DBT, New Delhi)

7.       Member: DBT-IAVI International Steering committee: 2008-2011

8.       RAP-SAC: National Institute of Immunology, New Delhi: 2009-2011;

9.       RAP-SAC: Central Drug Research Institute, Lucknow: 2009 – 2012;

10.    RAP-SAC: Institute of Microbial Technology, Chandigarh: 2012- ;

11.    IBSC Member: National Institute of Virology: DBT Nominee: 2007-2009

12.    IBSC member: INTOX- Pune: DBT nominee: 2012 - ;

13.    IBSC member: Serum Institute India Ltd.: 2012 – ;


Besides guiding PhD students to their degrees and guiding summer and project trainees, I have been involved in many administrative jobs in the Institute. A few of them are mentioned below:

  1. Selection and assessment of staff and students: National Centre for Cell Science (NCCS), National Institute of Virology (NIV), Rajendra Memorial Research Institute (RMRI) and National AIDS Research Institute (NARI);
  2. Project Review Committee and other committees: National Institute of Virology (NIV), Rajendra Memorial Research Institute (RMRI);
  3. Departmental meetings: including shuffling of staff between departments, stores and purchase policies, Institutional Animal Ethics committee, transgenic facility, animal housing, student accommodation, budgeting for instruments, core facilities, arbitration in personnel problems, etc.;
  4. On different policy issues on running the institute;
  5. Chief Vigilance Officer.

Member Since : 02nd February, 2016  | Profile Last Updated On : 07th March, 2023 9:46 PM
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