Sunday, 11th April, 1971 Same as Present Address Indian Male Ph.D. Teaching and Research Dept. of Physiology, West Bengal State University since March 20, 2009
1. High protein diet is beneficial in protecting the damaging effect of proteolytic enzymes in starvation (Master's Dissertation).
2. Established the molecular mechanism of immune evasion in hematological malignancies and propsed the case specific cell based therapies for leukemic patients. A rationale has been proposed for using PMNs in the management of leukemia (Ph.D. Thesis).
3. Analyzed HLA (Human Lymphocytic Antigen) transcriptosome and proposed the molecular rationale of HLA gene regulation by comparing the strength of constitutive and induced expression profiles (Ph.D. Thesis).
4. Delineation of cancer cachexia in leukemia by ultrastructural analysis of RBCs from leukemic patients.
5. Developed an automated algorithm for identification of cancer cachexia and/or pre-leukemia from peripheral blood.
6. Conventionally gene regulation is understood by forceful perturbation of genetic network in in vitro system. We have developed an Information Theory based Multivariate analytical model for understanding of gene regulation and/or down-stream target identification for human cancer.
7. Developed an in silico assessment of pharmacological and toxicological evaluation of cancer drugs and proposed for a replacement of animal use and long term assessment.
8. Psycho-neural control of immune regulation.
9. Developed an analytical (dynamical) model that can make a comparative assessment of different chemo-therapeutic strategies like conventional maximum tolerable dosing, anti-angiogenic drugs and metronomic chemotherapeutic dosing strategy, thereby long-term assessment of therapeutic outcome in cancer. Toxicity assessment and/or clinically relevant qualitative assessment can also be monitored by this model. This may help for apriori designing of suitable therapy of individual patients.
10. Developed an analytical (dynamical) model that can make a comparative assessment between different chemo-therapeutic, immune-boosting, stem-cell and immuno-gene therapy based strategies for the treatment of leukemia. This model also capable of predicting chonic GVHD for bone marrow transplantation. This may help for apriori designing of suitable therapy of individual patients.
11. Established new philosophical approach called “Middle-out Rationalist Approach (MORA)” in the area of Systems Biology. This could be ideal for translating Systems Biology to clinical arena, specially for poor Asian countries.
Department of Physiology, West Bengal State University as Assistant Professor [since March 20, 2009 to uptil now]
Department of Biophysics & Structural Genomics, Saha Institute of Nuclear Physics, Kolkata as UGC-NET (National Eligibility Test) Fellow [26-07-2000 to 26-07-2005]
Department of Hematology, School of Tropical Medicine, Kolkata as Prof. JB Chatterjee Memorial Research Fellow (Dept. of Health & Family Wefare, Govt. of W.B.)[Dec 1995-Sept 1999 (officially 31-01-1996 to 31-01-1998)]
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow as Senior Research Fellow, Dept. of Science & Technology, Govt. of India [11-09-1999 to 31-03-2000]
School of Information Technology, Bengal Engineering & Science University (presently IIEST) as Lecturer of Bioinformatics [March 01, 2006 to March 19, 2009]
Computer Science & Technology, BESU [10-04-2000 to 25-07-2000]
Das B, Majumder D* (2014). Interactions of Transcription Factors in HLA Class I transcriptosome, International Journal of Computer Information Systems & Industrial Management Applications, 6:592-602, ISSN: 2150-7988 (indexed in IET INSPEC & SCOPUS database) [Link: www.mirlabs.net/ijcisim/index.html]
Das B, Majumder D* (2013). Maximum Entropy based multivariate dependence analysis with a case study for HLA gene regulatory network in human leukemia, International Journal of Information Engineering, Volume 3(4): 137-142 [American V-King Scientific Publishing: 2225-8442 (Print), 2226-9721 (online)].
Das B, Majumder D* (2012). Information theory based analysis for understanding the regulation of HLA gene expression in human leukemia, International Journal of Information Sciences & Techniques, 2(5):39-50, doi: 10.5121/ijist.2012.2504 [Academy & Industry Research Collaboration Center (AIRCC): airccse.org]. [IF: 3.02].
Dutta G, Mondal N, Goswami A, Majumder D, Ghosh TK (2011). Effect of electrolytic lesion of medial septum on some immune resoses in rats, NeuroImmunoModulation, 18: 232-239, doi: 10.1159/000324122, [KARGER] (Accepted on Jan, 2011) [IF: 2.072].
Majumder D*, Mukherjee A. (2011) A passage through systems biology to systems medicine: adoption of middle-out rational approaches towards the understanding of clinical outcome in cancer therapy, Analyst, 136: 663-678, doi: 10.1039/c0an00746c [a journal by Royal Society of Chemistry], [Critical Review] [IF: 3.272].
Mukherjee A, Majumder D* (2010). Dynamical model for the assessment of anti-angiogenic therapy of cancer. Molecular BioSystems, 6:1047-1055 [a journal by Royal Society of Chemistry] [IF: 4.015].
Majumder D* (2010). Tumor angiogenesis based analytical model for the assessment of MCT and MTD chemotherapeutic strategies in cancer, Journal of Biological Systems, 18(4): 749-761, (Accepted on 28th Jan, 2010). [IF: 0.522]
Mukherjee S, Majumder D*(2009). Computational molecular docking assessment of hormone receptor adjuvant drugs: Breast cancer as an example, Pathophysiology [Elsevier (www.elsevier.com)], 16 (1): 19-29. (Accepted on 07-December, 2008) [IF: 1.263].
Mukherjee A, Majumder D* (2008) Mathematical modelling for the assessment of the effect of drug application delays in metronomic chemotherapy of cancer due to physiological constraints, BioSystems [Elsevier (www.elsevier.com)], 91(1):108-116 [IF: 1.267].
Majumder D, Mukherjee A (2007) Mathematical modeling of toxicity related trade-offs in metronomic chemotherapy, IET Systems Biology [www.theiet.org], 1(5): 298-305. [IF: 2.384]
Majumder D, Banerjee D, Chandra S, Banerjee SK, Chakrabarti A. (2006) Red cell morphology in leukemia, hypoplastic anemia and myelodysplastic syndrome, Pathophysiology [Elsevier (www.elsevier.com)], 13(4):217-225 [IF: 1.263].
Majumder D*, Mukherjee A. (2006) Pathophysiologically based logistics for the treatment of cancer, Journal of Biological Systems [World Scientific (www.worldscienet.com/jbs/14)], 14(4):631-650. [IF: 0.522].
Majumder D, Bandyopadhyay D, Chandra S, Mukhopadhayay A, Mukherjee N, Bandyopadyopadhyay SK, Banerjee S. (2005) Analysis of HLA class Ia transcripts in human leukemias, Immunogenetics (Springer), 57:579-589 [IF: 3.001].
Majumder D, Banerjee D, Chandra S, Mukherjee N, Banerjee S. (2006) Lack of HLA-E surface expression is due to deficiency of HLA-E transcripts in the malignant hematopoietic cells of leukemic patients, Leukemia Research [Elsevier (www.elsevier.com)], 30:242-245 [IF: 2.358].
Mukherjee A, Majumder D, Icbal A. (2006) Exploring the effectiveness of low continuous chemo-bio-therapeutic treatment of cancer through analytical system modelling, Journal of Biological Systems [World Scientific (www.worldscientific.com)], 14(1):1-12 [IF: 0.522].
Dutta N, Majumder D, Gupta A, Guha Mazumder DN, Banerjee S. (2005) Analysis of Human Lymphocyte Antigen class I expression in gastric cancer by reverse transcriptase polymerase chain reaction, Human Immunology [Elsevier (www.elsevier.com)], 66:164-169 [IF: 2.732].
Law S, Maiti D, Palit A, Majumder D, Basu K, Chaudhuri S, Chaudhuri S. (2001) Facilitation of functional compartmentalization of bone marrow cells in leukemic mice by biological response modifiers: an immunotherapeutic approach, Immunology Letters [Elsevier (www.elsevier.com)], 76:145-152 [IF: 2.908].
Law S, Maiti D, Palit A, Majumder D, Basu K, Chaudhuri S, Chaudhuri S. (1999) Biological response modifiers (BRMs) promotes functional compartmentalization in the bone marrow of leukemic mice: An immunological evaluation, Annals of National Academy of Medical Sciences (India), 35:97-107.
Dutta Chaudhuri M, Maity D, Palit A, Law S, Majumder D, Chaudhuri S. (1997) Cytotherapeutic approaches in CML patients: Effects of GCSF and CPM in combination, Indian Journal of Hematology & Blood Transfusion, 15 (Suppl. 1): 32.
Dhar PK, Naskar TK, Majumder D* (2018) An Analytical Approach for the Determination of Chemotherapeutic Drug Application Trade-offs in Leukemia, Paper ID 700, 3rd International Conference on Next Generation Computing Technologies (NGCT 2017), 30-31 Oct 2017, UPES, Dehradun, Bhattacharya P, Sastry HG, Venkatadri M, Sharma R (Eds.), Communications in Computer and Information Science 827, Springer, ISBN 978-981-10-8656-4 ISBN 978-981-10-8657-1 (eBook), pp. 390-404.
Dhar PK, Naskar TK, Majumder D* (2018) Optimal Choice between Chemotherapy and Immunotherapy for Leukemia Treatment Depends on Individual Patients' Pathophysiological State, Progress in Computing Analytics and Networking, Proceedings of ICCAN 2017, vol 710. pp. 643-653, Pattnaik PK, Rautaray SS, Das H, Nayak J (Editors), Progress in Computing, Analytics and Networking, Advances in Intelligent Systems and Computing 710, Springer, Singapore, DOI: https://doi.org/10.1007/978-981-10-7871-2_62, Print ISBN 978-981-10-7870-5, Online ISBN 978-981-10-7871-2.
Chatterjee G, Majumder D* (2017) Development of Algorithm for Detection of Malnutrition from Growth Dynamics Pattern in Children. In: Molecular Physiological and Nutritional Responses During Pathophysiological Alteration of Cell Function, pp. 131-136, Ghosh P, Giri B (Editors), Aaheli Publishers, ISBN 81-89169-33-5.
Paul R, Majumder D (2017) Development of Algorithm for Lorenz Equation through the Application of Open Source Software, In: Molecular Physiological and Nutritional Responses During Pathophysiological Alteration of Cell Function, pp. 45-57, Ghosh P, Giri B (Editors), Aaheli Publishers, ISBN 81-89169-33-5.
Majumder D. (2013) Application of Information theory for understanding of HLA gene regulation in leukemia. In: Advances in Computing & Information Technology, Vol. 177, pg. 161-173, Meghanathan N, Nagamalai D, Chaki N (Editors), Advances in Intelligent Systems and Computing, Kacprzyk J. (Series Editor), Springer-Verlag, ISSN: 2194-5357, ISBN 978-3-642-31551-0.
Majumder D. (2012) HLA Expression in Leukemia: Status, Regulation & Therapeutic Implications of HLA Expression in Leukemia, LAMBERT Academic Publishing GmbH & Co., Printed in USA & UK, ISBN: 978-3-8484-3247-9.
Das B, Majumder D* (2019). Differences of HLA Gene Regulatory Network in Human Myeloid and Lymphoid Leukemias, Proceedings of the International Conference on Bioinformatics and Systems Biology (BSB-2018), Paper 51 (accepted on 09-Aug-2018), ISBN: 978-1-5386-6434-6, 978-1-5386-6435-3 (print), doi: 10.1109/BSB.2018.8770568.
Dhar PK, Naskar TK, Majumder D* (2019) Prediction of Drug Application Optimization Based on RBC Dynamics in Maintenance Chemotherapy of Acute Lymphoblastic Leukemia: Maintenance Chemotheray in ALL, Proceedings of the International Conference on Bioinformatics and Systems Biology (BSB-2018), Paper 18 (accepted on 17-Aug-2018), ISBN: 978-1-5386-6434-6, 978-1-5386-6435-3 (print), doi:. 10.1109/BSB.2018.8770548.
Das M, Majumder D* (2017). Development of Algorithm for Gene Expression Analysis Through MaxEnt Based Multivariate Information Theory, Proceedings of the International Conference on Intelligent Communication and Computational Techniques 2017 (ICCT'17), pp. 217-222, Paper ID 195, Session 2 Big Data Computing, 22-24 Dec 2017, Manipal University, Jaipur, IEEE Conference No. 41378, Catalog No. CFP17L93ART (Xplore Compliant), ISBN 978-1-5386-3030-3, doi:10.1109/INTELCCT.2017.8324048.
Dhar PK, Naskar TK, Majumder D* (2017) Predictive Model for Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia, Proceedings of the International Conference on Intelligent Communication and Computational Techniques 2017 (ICCT'17), pp. 194-199, Paper ID 185, Session 7 Soft Computing, 22-24 Dec 2017, Manipal University, Jaipur, IEEE Conference No. 41378, Catalog No. CFP17L93ART (Xplore Compliant), ISBN 978-1-5386-3030-3, doi: 10.1109/INTELCCT.2017.8324044.
Das M, Majumder D* (2016). An analytical approach for leukemia diagnosis from light microscopic images of RBCs, Proceedings of the 2nd IEEE International Conference on Next Generation Computing Technologies (NGCT-2016), pp. 21-24, 14-16 Oct 2016, UPES, Dehradun, IEEE Conference No. 39694, doi: 10.1109/NGCT.2016.7877383, ISBN: 978-1-5090-3257-1.
Das B, Majumder D* (2012). Interactions among MARM binding factors. Proceedings of the 2012 World Congress on Information & Communication Technologies, Oct 30- Nov 02, 2012, Trivandrum, India, Paper 232, pp.191-196, Abraham A, Thampi SM, Pal S, Corchado E, Snasel V, Abraham S, Ramkrishnan S (Editors), IEEE Catalog Number: CFP1268R-CDR, ISBN: 978-1-4673-4804-1. (Accepted 18 September 2012).
Majumder D* (2012). Assessment of possible drug application delays in MCT strategy due to pathophysiological constraints of cancer, Proceedings of the 2012 World Congress on Information & Communication Technologies, IEEE WICT 2012, Oct 30- Nov 02, 2012, Trivandrum, India, Paper 233, pp.464-468, Abraham A, Thampi SM, Pal S, Corchado E, Snasel V, Abraham S, Ramkrishnan S (Editors), IEEE Catalog Number: CFP1268R-CDR, ISBN: 978-1-4673-4804-1. (Accepted 18 September 2012).
Bhattacharya S, Majumder D* (2009). An analytical approach for tracking the tumor system dynamics. IEEE – World Congress on Naturally and Biologically Inspired Computing (NaBIC 2009), Dec 9-11, 2009, Coimbatore, India, NABIC-124, pp. 92-97, doi: 10.1109/NABIC.2009.5393606, IEEE Catalog Number: CFP0995H-CDR, ISBN: 978-1-4244-5612-3, Print ISBN: 978-1-4244-5053-4, Library of Congress: 2009907135 [web: http://www.mirlabs.org/nabic09/index.html].
Barat S, Das A, Majumder D* (2009). Systems Biology Markup language for cancer system. IEEE – World Congress on Naturally and Biologically Inspired Computing (NaBIC 2009), Dec 9-11, 2009, Coimbatore, India, NABIC-S-07, pp. 1584-1587, doi: 10.1109/NABIC.2009.5393652, IEEE Catalog Number: CFP0995H-CDR, ISBN: 978-1-4244-5612-3, Print ISBN: 978-1-4244-5053-4, Library of Congress: 2009907135 [web: http://www.mirlabs.org/nabic09/index.html].
Majumder D*. (2004) Cancer immunity: Recent advances in Physiological research, Breakthrough, [Breakthrough Society (www.breakthrough-india.org)] 10:23-30. [ISSN 0974-2433].
Chaudhuri S., Maity D., Palit A., Majumder D., Law S., Duttachaudhuri M., Chaudhuri S. Immunokinetics of ex-vivo expanded bone marrow cells: BRM treatment to leukemic mice triggers greater immune-potentiation and protein tyrosine kinase (PTK) activity in expanded bone marrow cells. (1998) The Immunologist, Suppl. 1: 20.
1. Passed the National Eligibility Test (NET) Examination on July, 1999 and awarded the NET fellowship in the scheme of University Grants’ Commission (UGC), India and availed the Fellowship from 26th July, 2000 to 26th July, 2005.
2. Senior Research Fellowship (Department of Science and Technology, Govt. of India) from 11th Sept., 1999 to 31st March, 2000).
3. Prof. J.B. Chatterjee Memorial research Fellowship, Department of Health & Family Welfare, Govt. of West Bengal, India (from dated 31st Jan., 1996 to 31st Jan 1998).
The work published in Advances in Computing & Information Technology, Vol. 177, pg. 161-173, may produce considerable interest in the scientific community as evident by reprint request from Emeritus Prof. Arieh Ben-Naim, Dept. of Physical Chemistry, Hebrew University of Jerusalem, top 50 university of the world within a fortnight of the publication.
Our group has developed a new philosophical approach called "Middle-out Rationalist Approach (MORA)" in the area of Systems Biology. The works aimed at an analytical method for translating systems based therapeutic rationale in cancer that are more suited for the clinically feasible under the socio-economic structure of the developing countries. In this direction, we have published a considerable number of research papers. These make an interest to the scientific community as evident from the receiving innumerable number of reprints requests from the international scientific community. A review work described in detail have secured 1st position among the published paper in the area of Systems Biology in the year 2011 according to BioMedLib. Philosophically this work is in contrast to the practices in western science, hence has no influence and not an extrapolated version of work of any other laboratory. To the best of my knowledge this is the first published work on Systems Medicine from India.
This research work has been highlighted by Nature INDIA on its issue published on January 28, 2008.
This work has also been reported in National dailies ‘The Telegraph’ on its issue of Monday, May 19, 2008
Cited by Muhammad H Zaman in his article “The role of engineering approaches in analysing cancer invasion and metastasis” published in Nature reviews. Cancer 2013, 13:596-603
Five papers are cited in a single work of group from France who took a leading initiative on Metronomics Global Health Initiatives, Marseille, France [Ref: Andre et al, 2013, Mathematical model of cancer growth controlled by metronomic chemotherapies, ESIAM Proceedings, Vol 1, 1-10]
Expertise on Gene Expression is appreciated by Royal Society of Chemistry & Comment on the accepted paper has been cited in the journal of Royal Society of Chemistry
Academic Editor, Journal of Scientific Research & Reports, ScienceDomain International
Program/Committee Member of CCSIT 2014 (as on 16-July-2013)
Member, International Society for Systems Biology
Founder Secretary, Society for Systems Biology & Translational Research
Member Referee of the Royal Society of Chemistry (ID 244581)
Reviewer of :
Theoretical Biology & Medical Modelling
Procedia Computer Science
Journal of Biological Systems
International Journal of Information Technology, Control and Automation
Journal of Intelligent & Fuzzy Systems
Book Chapter 'Frontiers in Clinical Drug Research – Hematology' Prof. Atta-ur-Rahman, FRS (Ed.), Bentham Science Publishing.
Mr. Probir Kumar Dhar, M.Tech. (Electronics & Telecommunication) awarded with Ph.D. (Engineering) of Jadavpur University with the Joint Guidance of Prof. Tarun Kanti Naskar, Department of Mechanical Engineering, Jadavpur University. Thesis title – Application of Control Theory in The Understanding of Cancer Treatment Dynamics. Date of submission of thesis: 2018/04/12 Date of award: 2018/09/10.
Member Since : 08th October, 2013 | Profile Last Updated On : 26th October, 2019 1:29 PM
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